Food Area
Coleus Forskohlii from India
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Latin Name : Coleus forskohlii
Family : Lamiaceae
Sanskrit Name : Makandi
Common Name : Coleus, Mainmul, Karpuravali
Parts Used : Roots
Distribution : Coleus Forskohlii grows wild on sun-exposed arid and
semi-arid hill
slopes of the Himalayas in Uttar Pradesh (India) were from Simla Eastward
to Sikkim and Bhutan, Deccan Plateau, Eastern Ghats, Eastern Plateau
and rain shadow regions of the Western Ghats in India.
INTRODUCTION : Coleus forskohlii is
part of the mint family of plants and has long been cultivated in India,
Thailand and parts of SE Asia as a spice and as a condiment for heart
ailments and stomach cramps. The roots of the plant are a natural source
of forskolin, the only plant-derived compound presently known to directly
stimulate the enzyme adenylate cyclase, and subsequently cyclic AMP.
PLANT DESCRIPTION : This species is
a perennial herb with fleshy, fibrous roots that grows wild in the warm
subtropical temperate areas in India, Burma and Thailand. It is one
of the 150 coleus species, which are commonly cultivated as ornamental
plants, because of their colorful foliage. The roots of C. forskohlii,
unlike other coleus species, are used for health purposes.
DISCOVERY OF FORSKOLIN : Coleus forskohlii
belonging to the family Labiatae was collected in 1973 from Dehra Dun
in North India for targeted pharmacological screening for its phylogenetic
relationship to a medicinal herb, C. amboinicus. Diterpene Forskolin
was derived as active alkaloid from the roots.
PHYTOCHEMICALS : Chief alkaloid found
is Forskohlii. Many other diterpenoids as deacetyl forskolin, 9-deoxyforskolin,
1, 9-deoxyforskolin,1, 9-dideoxy- 7-deacetylforskolin have been isolated.
Other minor phytochemicals are allylroyleanone, barbatusin, plectrin,
plectirinon A, acetoxycoleosol, coleol, coleonone, coleosol, deoxycoleonol,
crocetin dialehyde, napthopyrones.
PHARMACOKINETICS : Many of its effects come from a
resultant increase in an enzyme called adenylate cyclase which increases
the amount of cellular cyclic
adenosine monophosphate (cAMP) which activates many other enzymes involved
in diverse cellular functions. Increased cellular cAMP levels cause
several physiological and biochemical effects such as :
- Inhibition of platelet activation and degranulation.
- Inhibition of mast cell degranulation and release of histamine and other allergic compounds.
- Increased force of contraction of the heart muscle.
- Relaxation of the arteries and other smooth muscles, vasodilation.
- Increased insulin secretion.
- Increased thyroid function (and therefore metabolic rate).
- Reduced adipose assimilation and increased lipolysis
of fats.
ACTION: Anti-glaucoma, Anti-platelet,
Bronchospasmolyltic, Cardiotonic, Hypotensive, Anti aging, Anti allergic,
Smooth muscle and arterial relaxant, Antiasthmatic.
USES AND BENEFITS OF COLEUS :
Coleus is found to be effective in skin conditions as eczema and psoriasis.
Coleus is primarily indicated for cardiovascular diseases including hypertension, congestive heart failure and angina.
Studies have indicated the use of coleus for asthma, intestinal colic, uterine cramps, as well as painful urination.
Coleus can aid in weight loss due to its ability to
breakdown stored fat as well as inhibit the synthesis of adipose tissue,
additionally, it increases thyroid hormone
production and release thereby increasing metabolism.
Ophthalmic preparation of forskolin to the eyes lowers
eye pressure thus
reducing the risk of Glaucoma. Coleus can aid in digestive and malabsorption
disorders through its ability to stimulate secretion of saliva, hydrochloric
acid, pepsin, amalyase and pancreatic enzymes and increase nutrient
absorption in the small intestine
Coleus Extract
Specification Sheet
INTRODUCTION: Coleus forskohlii Herb Extract the only
plant source of active
gredientforskolin. Forskolin's basic mechanism of action is that it
increases the amount of cyclic AMP (adenosine monophosphate) in cells
by activating an enzyme called adenylate cyclase. Cyclic AMP (cAMP)
is one of the most important secondary messengers in the cell. It is
considered to be one of the most important cell regulating compounds.
MANUFACTURING PROCESS: To make Coleus Extract the
dry coleus roots are collected, cleaned to remove the physical impurities,
like adhered soil and dirt. Then the dried roots are grinded to make
it powder form. After that it is extract by suitable extractor and aseptic
packaging for the further storage and transportation.
HOW IT WORKS : Under normal circumstances, cAMP forms by adenylate cyclase
activation due to hormonal stimulation at the cell receptor site. However,
forskolin seems to bypass this reaction and allows for an increase in
intracellular cAMP to occur.
BENEFITS OF COLEUS EXTRACT:
Forskolin has been shown to be safe and effective and has a great amount
of potential as a sports supplement. There are several benefits to athletes
including relaxation of the arteries and smooth muscles, lowering blood
pressure, enhanced insulin secretion; which can help drive carbohydrates
and protein into muscle cells for energy and recovery, increased thyroid
hormone function; which can help enhance metabolic rate, and significantly
increase lipolysis.
Forskolin seems to benefit other cellular enzymes as well. The breakdown
of fat for fuel is actually regulated by cAMP. Forskolin has been shown
to not only enhance lipolysis but it may also inhibit fat storage from
occurring. Another
way that forskolin may allow for fat loss to occur is by stimulating
thyroid hormone production and release. Thyroid hormone controls metabolism
and can enhance metabolic rate, which may translate into more fat loss.
One of the overlooked benefits of forskolin includes its stimulation of digestive enzymes, which allows individuals to digest and assimilate their food better. It has been shown to increase nutrient absorption in the small intestine.
Highlights of Our Product
- ISO 9000 certified manufacturing unit.
- Organic raw material through dedicated farmers and supplier of raw-material.
- cGMP, manufacturing and Good Lab Practice.
- Quality specification, with microbial level less than 300 CFU/g and
free from yeast, mold and other contaminants.
- Free from any heavy metal Content.
- Only available in Bulk (minimum quantity 100 Kg).
- Customized and contract manufacturing as per customer requirement.
Coleus Powder
INTRODUCTION: Native to the subtropical regions of India, Myanmar and Thailand, Coleus root powder is a spice and medicinal herb with a long history of usage in Ayurvedic medicine. The root of coleus contains the highest levels of the active ingredient, forskolin. A perennial herb growing wild in the warm temperate areas in India, powder of coleus root, may help dilate blood vessels and improve the forcefulness with which the heart pumps blood.
MANUFACTURING PROCESS OF COLEUS POWDER: Coleus powder is processed from Dry Coleus Roots. The Coleus roots are first washed thoroughly to remove physical impurities. After washing, the Coleus roots are pulped. Pulping of Coleus roots is followed by sun drying to reduce its moisture content. The product obtained is then grinded and sieved to obtain fine powdered coleus root. After this , the dry Coleus root powder is packed airtight for storage and transportation.
HISTORY OF COLEUS USE IN INDIA : In India, it is cultivated for use as a condiment. It is also been grown as an ornamental herb.
PHARMACOLOGY: The main action of forskolin is to
activate adenyl cyclase, an enzyme responsible for the conversion of
ATP to cyclic adenosine mono phosphate (cAMP). Cyclic AMP is one of
the most important “second messengers”, a signaling hormone system in
cell regulation. Most water-soluble hormones cannot cross the cell membrane,
but instead cause the acquired effects within cells via these second
messengers. Raised intracellular cAMP level will have physiological
and biochemical effects like, parathyroid hormone causes the reabsorption
of calcium from bone, vasopressin in kidney helps the reabsorption of
water and trigliyceride (fat) breakdown in fat cells and increased thyroid
functions.
Lipolysis (breakdown of fat) is largely governed by the amount of cAMP
circulating in cells. Cyclic AMP will activates protein kinasea which
stimulates the release of fatty acids from fat cells.
BENEFITS AND USES:
- Coleus powder is used as a condiment in various food preparations.
- Also has a thyroid-stimulating action, which contributes to thermogenesis
and an ncrease in the basal metabolic rate.
- Glaucoma Studies in healthy humans, including at least one double-blind
trial,
have shown that direct application of an ophthalmic preparation of forskolin
to the
eyes lowers eye pressure, thus reducing the risk of glaucoma.
- A small double-blind trial found that inhaled forskolin could decrease
lung
spasms in asthmatics.
Highlights of Our Product :
- ISO 9000 certified manufacturing unit.
- Organic raw material through dedicated farmers and supplier of raw-material.
- cGMP, manufacturing and Good Lab Practice.
- Quality specification, with microbial level less than 300 CFU/g and
free from yeast, mold and other contaminants.
- Free from any heavy metal Content.
- Only available in Bulk (minimum quantity 100 Kg).
- Customized and contract manufacturing as per customer requirement.
Coleus Research
INTRODUCTION: In recent years, Coleus forskohlii has gained recognition As the only known plant source of the diterpene, Forskolin. Forskolin is valued as an adenylate cyclase activator. The role of cyclic AMP is indispensable to many body functions. Intensive research has been carried on since 1974 for its use as a food supplements and subsequently as a drug.
- The latest news on the thermogenic circuit is coleus forskohlii.
Research on the active compound forskolin was performed at the University
of Memphis. In one study, weight loss from the forskolin group exceeded
that of the placebo group (both groups exercised); appears to have some
benefit. Toxicity data is still limited.